| First Author | Liu C | Year | 2010 |
| Journal | Nat Neurosci | Volume | 13 |
| Issue | 10 | Pages | 1190-8 |
| PubMed ID | 20818386 | Mgi Jnum | J:165266 |
| Mgi Id | MGI:4836772 | Doi | 10.1038/nn.2623 |
| Citation | Liu C, et al. (2010) Pet-1 is required across different stages of life to regulate serotonergic function. Nat Neurosci 13(10):1190-8 |
| abstractText | Transcriptional cascades are required for the specification of serotonin (5-HT) neurons and behaviors modulated by 5-HT. Several cascade factors are expressed throughout the lifespan, which suggests that their control of behavior might not be temporally restricted to programming normal numbers of 5-HT neurons. We used new mouse conditional targeting approaches to investigate the ongoing requirements for Pet-1 (also called Fev), a cascade factor that is required for the initiation of 5-HT synthesis, but whose expression persists into adulthood. We found that Pet-1 was required after the generation of 5-HT neurons for multiple steps in 5-HT neuron maturation, including axonal innervation of the somatosensory cortex, expression of appropriate firing properties, and the expression of the Htr1a and Htr1b autoreceptors. Pet-1 was still required in adult 5-HT neurons to preserve normal anxiety-related behaviors through direct autoregulated control of serotonergic gene expression. These findings indicate that Pet-1 is required across the lifespan of the mouse and that behavioral pathogenesis can result from both developmental and adult-onset alterations in serotonergic transcription. |
