| First Author | Musteanu M | Year | 2012 |
| Journal | Nat Methods | Volume | 9 |
| Issue | 9 | Pages | 897-900 |
| PubMed ID | 22863881 | Mgi Jnum | J:226601 |
| Mgi Id | MGI:5697943 | Doi | 10.1038/nmeth.2130 |
| Citation | Musteanu M, et al. (2012) A mouse model to identify cooperating signaling pathways in cancer. Nat Methods 9(9):897-900 |
| abstractText | We here establish a mouse cancer model called Multi-Hit that allows for the evaluation of oncogene cooperativities in tumor development. The model is based on the stochastic expression of oncogene combinations ('hits') that are mediated by Cre in a given tissue. Cells with cooperating hits are positively selected and give rise to tumors. We used this approach to evaluate the requirement of Ras downstream effector pathways in tumorigenesis. |
