| First Author | Fu G | Year | 2010 |
| Journal | J Exp Med | Volume | 207 |
| Issue | 2 | Pages | 309-18 |
| PubMed ID | 20123962 | Mgi Jnum | J:157757 |
| Mgi Id | MGI:4436940 | Doi | 10.1084/jem.20090880 |
| Citation | Fu G, et al. (2010) Phospholipase C{gamma}1 is essential for T cell development, activation, and tolerance. J Exp Med 207(2):309-18 |
| abstractText | Phospholipase Cgamma1 (PLCgamma1) is an important signaling effector of T cell receptor (TCR). To investigate the role of PLCgamma1 in T cell biology, we generated and examined mice with T cell-specific deletion of PLCgamma1. We demonstrate that PLCgamma1 deficiency affects positive and negative selection, significantly reduces single-positive thymocytes and peripheral T cells, and impairs TCR-induced proliferation and cytokine production, and the activation of ERK, JNK, AP-1, NFAT, and NF-kappaB. Importantly, PLCgamma1 deficiency impairs the development and function of FoxP3(+) regulatory T cells, causing inflammatory/autoimmune symptoms. Therefore, PLCgamma1 is essential for T cell development, activation, and tolerance. |
