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Allele : Cebpa<tm1Kgx> CCAAT/enhancer binding protein alpha; targeted mutation 1, Kleanthis G Xanthopoulos

Primary Identifier  MGI:2177068 Allele Type  Targeted
Attribute String  Null/knockout Gene  Cebpa
Transmission  Germline Strain of Origin  (129X1/SvJ x 129S1/Sv)F1-Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin resistance cassette was inserted downstream of both translation initiation codons, resulting in stop codons in all three reading frames. Northern blot analysis on RNA derived from liver of homozygous mice demonstrated that a large fusion transcript was made that incorporated both the gene and the neomycin cassette elements. However, western blot experiments on liver lysates from homozygous mice confirmed that no detectable protein was expressed from this allele.
  • mutations:
  • Insertion
  • synonyms:
  • Cebpa<->,
  • C/EBPalpha-,
  • Cebpa<->,
  • C/EBPalpha-
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

0 Carried By

0 Driven By

8 Publication categories