| First Author | Banner LR | Year | 1998 |
| Journal | J Neurosci | Volume | 18 |
| Issue | 14 | Pages | 5456-62 |
| PubMed ID | 9651226 | Mgi Jnum | J:119777 |
| Mgi Id | MGI:3703259 | Doi | 10.1523/JNEUROSCI.18-14-05456.1998 |
| Citation | Banner LR, et al. (1998) Leukemia inhibitory factor is an anti-inflammatory and analgesic cytokine. J Neurosci 18(14):5456-62 |
| abstractText | The mRNA for leukemia inhibitory factor (LIF), a neuroimmune signaling molecule, is elevated during skin inflammation produced by intraplantar injection of complete Freund's adjuvant (CFA). Moreover, although LIF knock-out mice display normal sensitivity to cutaneous mechanical and thermal stimulation compared with wild-type mice, the degree of CFA-induced inflammation in mice lacking LIF is enhanced in spatial extent, amplitude, cellular infiltrate, and interleukin (IL)-1beta and nerve growth factor (NGF) expression. Conversely, local injection of low doses of recombinant LIF diminishes mechanical and thermal hypersensitivity as well as the IL-1beta and NGF expression induced by CFA. These data show that upregulation of LIF during peripheral inflammation serves a key, early anti-inflammatory role and that exogenous LIF can reduce inflammatory hyperalgesia. |
