| First Author | Igakura T | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 224 |
| Issue | 1 | Pages | 33-6 |
| PubMed ID | 8694829 | Mgi Jnum | J:34103 |
| Mgi Id | MGI:81577 | Doi | 10.1006/bbrc.1996.0980 |
| Citation | Igakura T, et al. (1996) Roles of basigin, a member of the immunoglobulin superfamily, in behavior as to an irritating odor, lymphocyte response, and blood-brain barrier. Biochem Biophys Res Commun 224(1):33-6 |
| abstractText | Basigin is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Using the knockout mouse lacking the basigin gene (Bsg), we analyzed the function of basigin in adult mice lacking the gene [Bsg (-1-)]. Although histochemical studies on the localization of basigin (also called HT7 and neurothelin) strongly indicated that it is involved in the function of the blood-brain barrier, basigin knockout mice showed only a little difference, if any, to wild-type mice in the function of the blood brain-barrier. The mitogenic response of lymphocytes upon mixed lymphocyte reaction was greater in Bsg (-1-) mice. Finally, Bsg (-1-) mice repeatedly visited filter paper impregnated with acetic acid or isozine, indicating an abnormality in either reception of the odor or behavior as to it. |
