| First Author | Eden S | Year | 2001 |
| Journal | EMBO J | Volume | 20 |
| Issue | 13 | Pages | 3518-25 |
| PubMed ID | 11432838 | Mgi Jnum | J:178292 |
| Mgi Id | MGI:5298099 | Doi | 10.1093/emboj/20.13.3518 |
| Citation | Eden S, et al. (2001) An upstream repressor element plays a role in Igf2 imprinting. EMBO J 20(13):3518-25 |
| abstractText | The imprinted Igf2 gene is associated with a small upstream region that is differentially methylated on the active paternal allele. We have identified a repressor element within this sequence and shown that repression is probably mediated through a trans- acting factor, GCF2. DNA methylation of this site abrogates both protein binding and repressor activity. Targeting experiments demonstrate that this element plays a role in the repression of the maternal Igf2 gene in vivo. |
