| First Author | Jandke A | Year | 2020 |
| Journal | Nat Commun | Volume | 11 |
| Issue | 1 | Pages | 3769 |
| PubMed ID | 32724083 | Mgi Jnum | J:291989 |
| Mgi Id | MGI:6447449 | Doi | 10.1038/s41467-020-17557-y |
| Citation | Jandke A, et al. (2020) Butyrophilin-like proteins display combinatorial diversity in selecting and maintaining signature intraepithelial gammadelta T cell compartments. Nat Commun 11(1):3769 |
| abstractText | Butyrophilin-like (Btnl) genes are emerging as major epithelial determinants of tissue-associated gammadelta T cell compartments. Thus, the development of signature, murine TCRgammadelta(+) intraepithelial lymphocytes (IEL) in gut and skin depends on Btnl family members, Btnl1 and Skint1, respectively. In seeking mechanisms underlying these profound effects, we now show that normal gut and skin gammadelta IEL development additionally requires Btnl6 and Skint2, respectively, and furthermore that different Btnl heteromers can seemingly shape different intestinal gammadelta(+) IEL repertoires. This formal genetic evidence for the importance of Btnl heteromers also applied to the steady-state, since sustained Btnl expression is required to maintain the signature TCR.Vgamma7(+) IEL phenotype, including specific responsiveness to Btnl proteins. In sum, Btnl proteins are required to select and to maintain the phenotypes of tissue-protective gammadelta IEL compartments, with combinatorially diverse heteromers having differential impacts on different IEL subsets. |
