| First Author | Bain G | Year | 1997 |
| Journal | Immunity | Volume | 6 |
| Issue | 2 | Pages | 145-54 |
| PubMed ID | 9047236 | Mgi Jnum | J:38711 |
| Mgi Id | MGI:86093 | Doi | 10.1016/s1074-7613(00)80421-5 |
| Citation | Bain G, et al. (1997) Both E12 and E47 allow commitment to the B cell lineage. Immunity 6(2):145-54 |
| abstractText | The E2A gene products, E12 and E47, are required for proper B cell development. Mice lacking the E2A gene products generate only a very small number of B220+ cells, which lack immunoglobulin DJ(H) rearrangements. We have now generated mice expressing either E12 or E47. B cell development in mice expressing E12 but lacking E47 is perturbed at the pro-B cell stage, and these mice lack IgM+B220+ B cells in both bone marrow and spleen. IgM+B220+ B cells can be detected, albeit at significantly reduced levels, in the bone marrow and spleen of mice lacking E12. Ectopic expression of both E12 and E47 in a null mutant background shows that E12 and E47 act in concert to promote B lineage development. Taken together, the data indicate that both E12 and E47 allow commitment to the B cell lineage and act synergistically to promote B lymphocyte maturation. |
