| First Author | Persico AM | Year | 2003 |
| Journal | Neuroreport | Volume | 14 |
| Issue | 3 | Pages | 341-4 |
| PubMed ID | 12634480 | Mgi Jnum | J:89816 |
| Mgi Id | MGI:3041675 | Doi | 10.1097/00001756-200303030-00009 |
| Citation | Persico AM, et al. (2003) Reduced programmed cell death in brains of serotonin transporter knockout mice. Neuroreport 14(3):341-4 |
| abstractText | Serotonin (5-HT) is known to reduce apoptosis and in rodent models of brain ischemia. Modulation of programmed cell death during neural development was assessed in early postnatal brains of serotonin transporter (5-HTT) knockout mice, characterized by elevated extracellular 5-HT levels. The number of apoptotic cells visualized at postnatal day-1 (P1) by ISEL+ or TUNEL staining was significantly reduced in the striatum, thalamus/hypothalamus, cerebral cortex and hippocampus of 5-HTT knockout mice, compared to wild type and heterozygote mice, with differences displaying an increasing fronto-caudal gradient and regional specificity. These findings underscore 5-HT roles in the regulation of programmed cell death during brain development, and spur interest into pharmacological interventions aimed at relieving pathological apoptosis by potentiating serotoninergic neurotransmission. |
