| First Author | Massari P | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 4 | Pages | 1533-7 |
| PubMed ID | 11823477 | Mgi Jnum | J:74463 |
| Mgi Id | MGI:2158517 | Doi | 10.4049/jimmunol.168.4.1533 |
| Citation | Massari P, et al. (2002) Cutting edge: immune stimulation by neisserial porins is toll-like receptor 2 and MyD88 dependent. J Immunol 168(4):1533-7 |
| abstractText | The immunopotentiating activity of neisserial porins, the major outer membrane protein of the pathogenic Neisseria, is mediated by its ability to stimulate B cells and up-regulate the surface expression of B7-2. This ability is dependent on MyD88 and Toll-like receptor (TLR)2 expression, as demonstrated by a lack of a response by B cells from MyD88 or TLR2 knockout mice to the porins. Using previously described TLR2-dependent reporter constructs, these results were confirmed and were shown to be due to induction of NF-kappaB nuclear translocation. This is the first demonstration of known vaccine adjuvant to stimulate immune cells via TLR2. |
