| Primary Identifier | MGI:2179066 | Allele Type | Transgenic |
| Attribute String | Null/knockout, Transactivator | Gene | Tg(Camk2a-tTA)1Mmay |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| description | This transgene is line B. Transgenic mice are viable, fertile, and display no overt phenotypic defects. Administration of tetracycline analogs such as doxycycline blocks transgene expression. |
| molecularNote | The transgene contains the tetracycline-controlled transactivator protein (tTA) under regulatory control of the forebrain specific calcium/calmodulin-dependent kinase II promoter. The transgene integrated into chromosome 12 causing a 508.12 Kb deletion and disrupting the following genes: Vipr2, Wdr60, Esyt2, Ncapg2, and Ptprn2. The deletion results in a functional knock-out of Vipr2, Wdr60, Esyt2, and Ncapg2 in homozygous mice. Founder line 1 has a copy number of greater than 20. |
