| First Author | Fasano S | Year | 2009 |
| Journal | Front Behav Neurosci | Volume | 3 |
| Pages | 29 | PubMed ID | 19826621 |
| Mgi Jnum | J:180421 | Mgi Id | MGI:5306224 |
| Doi | 10.3389/neuro.08.029.2009 | Citation | Fasano S, et al. (2009) Inhibition of CREB activity in the dorsal portion of the striatum potentiates behavioral responses to drugs of abuse. Front Behav Neurosci 3:29 |
| abstractText | The striatum participates in multiple forms of behavioral adaptation, including habit formation, other forms of procedural memory, and short- and long-term responses to drugs of abuse. The cyclic-AMP response element binding protein (CREB) family of transcription factors has been implicated in various forms of behavioral plasticity, but its role in the dorsal portion of the striatum-has been little explored. We previously showed that in transgenic mice in which CREB function is inhibited in the dorsal striatum, bidirectional synaptic plasticity and certain forms of long-term procedural memory are impaired. Here we show, in startling contrast, that inhibition of striatal CREB facilitates cocaine- and morphine-place conditioning and enhances locomotor sensitization to cocaine. These findings propose CREB as a positive regulator of dorsal striatum-dependent procedural learning but a negative regulator of drug-related learning. |
