| First Author | Ranganathan GN | Year | 2018 |
| Journal | Nat Neurosci | Volume | 21 |
| Issue | 11 | Pages | 1583-1590 |
| PubMed ID | 30349100 | Mgi Jnum | J:271575 |
| Mgi Id | MGI:6279585 | Doi | 10.1038/s41593-018-0254-6 |
| Citation | Ranganathan GN, et al. (2018) Active dendritic integration and mixed neocortical network representations during an adaptive sensing behavior. Nat Neurosci 21(11):1583-1590 |
| abstractText | Animals strategically scan the environment to form an accurate perception of their surroundings. Here we investigated the neuronal representations that mediate this behavior. Ca(2+) imaging and selective optogenetic manipulation during an active sensing task reveals that layer 5 pyramidal neurons in the vibrissae cortex produce a diverse and distributed representation that is required for mice to adapt their whisking motor strategy to changing sensory cues. The optogenetic perturbation degraded single-neuron selectivity and network population encoding through a selective inhibition of active dendritic integration. Together the data indicate that active dendritic integration in pyramidal neurons produces a nonlinearly mixed network representation of joint sensorimotor parameters that is used to transform sensory information into motor commands during adaptive behavior. The prevalence of the layer 5 cortical circuit motif suggests that this is a general circuit computation. |
