| First Author | Suzuki-Yamamoto T | Year | 2009 |
| Journal | J Lipid Res | Volume | 50 |
| Issue | 10 | Pages | 1996-2003 |
| PubMed ID | 19429887 | Mgi Jnum | J:154143 |
| Mgi Id | MGI:4367327 | Doi | 10.1194/jlr.M800543-JLR200 |
| Citation | Suzuki-Yamamoto T, et al. (2009) Colocalization of prostaglandin F2alpha receptor FP and prostaglandin F synthase-I in the spinal cord. J Lipid Res 50:1996-2003 |
| abstractText | Prostaglandin F(2a) is synthesized by prostaglandin F synthase, which exists in two types, prostaglandin F synthase I (PGFS I) and prostaglandin F synthase II (PGFS II). Prostaglandin F(2a) binds to its specific receptor, FP. Our previous immunohistochemical study showed the distinct localization of prostaglandin F synthases in rat spinal cord. PGFS I exists in neuronal somata and dendrites in the gray matter, and PGFS II exists in ependymal cells and tanycytes surrounding the central canal. Both enzymes are also present in endothelial cells of blood vessels in the white and gray substances of the spinal cord. In the present study, we found that FP localizes in neuronal somata and dendrites, but not in ependymal cells, tanycytes, or endothelial cells. Immunohistochemical analysis of serial sections showed the colocalization of FP and PGFS I. FP immunoreactivity was intense in spinal laminae I and II of the dorsal horn, a connection site of pain transmission, and was similar to that of PGFS I in neuronal elements. These findings suggest that prostaglandin F(2a) synthesized in the neuronal somata and dendrites exert an autocrine action there. |
