| First Author | Crowston JG | Year | 2004 |
| Journal | Invest Ophthalmol Vis Sci | Volume | 45 |
| Issue | 10 | Pages | 3555-9 |
| PubMed ID | 15452062 | Mgi Jnum | J:109786 |
| Mgi Id | MGI:3629831 | Doi | 10.1167/iovs.04-0338 |
| Citation | Crowston JG, et al. (2004) Effect of latanoprost on intraocular pressure in mice lacking the prostaglandin FP receptor. Invest Ophthalmol Vis Sci 45(10):3555-9 |
| abstractText | PURPOSE: To determine whether latanoprost lowers IOP in prostaglandin FP receptor knockout mice. METHODS: Mean IOP difference between treated and untreated fellow eyes was measured on three separate occasions, 2 hours after a 200-ng dose of latanoprost to the right eye of homozygous (n = 9) and heterozygous (n = 15) FP knockout mice. C57BL/6 (n = 10) and NIH Swiss white mice (n = 17), which have normal FP receptor expression, provided the control population. The investigator was masked to the genotype of the FP knockout mice at the time of IOP measurement. RESULTS: Latanoprost had no effect on IOP in the homozygous FP knockout mice, with an average difference in IOP between treated and untreated fellow eyes of +0.25 mm Hg and a 95% confidence interval (CI) for the difference between means of -0.019 to +0.69. In contrast, latanoprost reduced IOP in the treated eye of the heterozygous FP knockout, C57BL/6, and Swiss white mice with mean differences and 95% CI of the difference in means of -0.52 (-0.91 to -0.14), -1.38 (-2.1 to -0.70), and -1.29 (-1.78 to -0.79) mm Hg, respectively. CONCLUSIONS: FP receptor signaling plays a crucial role in the early IOP response to latanoprost in the mouse eye. |
