| First Author | Schmitt WB | Year | 2005 |
| Journal | Nat Neurosci | Volume | 8 |
| Issue | 3 | Pages | 270-2 |
| PubMed ID | 15723058 | Mgi Jnum | J:97573 |
| Mgi Id | MGI:3575856 | Doi | 10.1038/nn1412 |
| Citation | Schmitt WB, et al. (2005) Restoration of spatial working memory by genetic rescue of GluR-A-deficient mice. Nat Neurosci 8(3):270-2 |
| abstractText | Gene-targeted mice lacking the AMPA receptor subunit GluR-A (also called GluR1 encoded by the gene Gria1,) have deficits in hippocampal CA3-CA1 long-term potentiation (LTP) and have profoundly impaired hippocampus-dependent spatial working memory (SWM) tasks, although their spatial reference memory remains normal. Here we show that forebrain-localized expression of GFP-tagged GluR-A subunits in GluR-A-deficient mice rescues SWM, paralleling its rescue of CA3-CA1 LTP. This provides powerful new evidence linking hippocampal GluR-A-dependent synaptic plasticity to rapid, flexible memory processing. |
