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Publication : Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex.

First Author  Wright N Year  2008
Journal  Nat Neurosci Volume  11
Issue  10 Pages  1140-2
PubMed ID  18776896 Mgi Jnum  J:141146
Mgi Id  MGI:3817344 Doi  10.1038/nn.2188
Citation  Wright N, et al. (2008) Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex. Nat Neurosci 11(10):1140-2
abstractText  Several synaptic depression mechanisms have been described for the hippocampus, cerebellum and neocortex in vitro, but little is known about which, if any, are engaged during experience-dependent depression (EDD). We found that EDD in the mouse barrel cortex depends on the AMPA subunit GluR1 in layers II/III and IV, but not in layer V, and that long-term depression is also GluR1 dependent in the IV-II/III, but not II/III-V, pathway.
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