| Primary Identifier | MGI:2178387 | Allele Type | Chemically induced (ENU) |
| Gene | Egfr | Inheritance Mode | Semidominant |
| Strain of Origin | BALB/cAnN | Is Recombinase | false |
| Is Wild Type | false | Project Collection | Harwell ENU Mutagenesis |
| description | This allele contains the same point mutation as in EgfrVel in a different ENU screen and strain. Both alleles are considered antimorphs. |
| molecularNote | Originally named Waved 5, this phenotypic mutant was deemed allelic to Egfr when it failed to complement Egfrtm1Mag. The entire coding region of Egfr was subsequently sequenced. A single point mutation was found causing a GAT to GGT missense mutation in exon 21. This results in an aspartic acid to glycine change at amino acid residue 833 altering a DFG motif critical to the tyrosine kinase function of this gene. |
