| First Author | Sillaber I | Year | 2002 |
| Journal | Science | Volume | 296 |
| Issue | 5569 | Pages | 931-3 |
| PubMed ID | 11988580 | Mgi Jnum | J:76358 |
| Mgi Id | MGI:2179180 | Doi | 10.1126/science.1069836 |
| Citation | Sillaber I, et al. (2002) Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science 296(5569):931-3 |
| abstractText | There is a relation between stress and alcohol drinking. We show that the corticotropin-releasing hormone (CRH) system that mediates endocrine and behavioral responses to stress plays a role in the control of long-term alcohol drinking. In mice lacking a functional CRH1 receptor, stress leads to enhanced and progressively increasing alcohol intake. The effect of repeated stress on alcohol drinking behavior appeared with a delay and persisted throughout life. It was associated with an up-regulation of the N-methyl-d-aspartate receptor subunit NR2B. Alterations in the CRH1 receptor gene and adaptional changes in NR2B subunits may constitute a genetic risk factor for stress-induced alcohol drinking and alcoholism. |
