| First Author | Nie Z | Year | 2004 |
| Journal | Science | Volume | 303 |
| Issue | 5663 | Pages | 1512-4 |
| PubMed ID | 15001778 | Mgi Jnum | J:89714 |
| Mgi Id | MGI:3041316 | Doi | 10.1126/science.1092550 |
| Citation | Nie Z, et al. (2004) Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Science 303(5663):1512-4 |
| abstractText | The central amygdala (CeA) plays a role in the relationship among stress, corticotropin-releasing factor (CRF), and alcohol abuse. In whole-cell recordings, both CRF and ethanol enhanced gamma-aminobutyric acid-mediated (GABAergic) neurotransmission in CeA neurons from wild-type and CRF2 receptor knockout mice, but not CRF1 receptor knockout mice. CRF1 (but not CRF2) receptor antagonists blocked both CRF and ethanol effects in wild-type mice. These data indicate that CRF1 receptors mediate ethanol enhancement of GABAergic synaptic transmission in the CeA, and they suggest a cellular mechanism underlying involvement of CRF in ethanol's behavioral and motivational effects. |
