| First Author | Kouznetsova A | Year | 2007 |
| Journal | Nat Genet | Volume | 39 |
| Issue | 8 | Pages | 966-8 |
| PubMed ID | 17618286 | Mgi Jnum | J:123509 |
| Mgi Id | MGI:3718753 | Doi | 10.1038/ng2065 |
| Citation | Kouznetsova A, et al. (2007) Bi-orientation of achiasmatic chromosomes in meiosis I oocytes contributes to aneuploidy in mice. Nat Genet 39(8):966-8 |
| abstractText | The spindle assembly checkpoint guards against chromosomal missegregation but does not induce arrest in oocytes that contain a few achiasmatic chromosomes (univalents). We followed the fate of univalents in oocytes during the first meiotic division, and although these preserved a meiotic kinetochore structure, they were also bi-oriented in a mitotic manner. The hybrid chromosomal configuration attained by univalents allows them to evade the spindle assembly checkpoint and contribute to aneuploidy in oocytes. |
