| First Author | Tajiri S | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 14 | Pages | 3462-8 |
| PubMed ID | 16716308 | Mgi Jnum | J:109623 |
| Mgi Id | MGI:3629373 | Doi | 10.1016/j.febslet.2006.05.021 |
| Citation | Tajiri S, et al. (2006) CHOP is involved in neuronal apoptosis induced by neurotrophic factor deprivation. FEBS Lett 580(14):3462-8 |
| abstractText | Neurotrophic factors are essential for the survival of neurons. We found that the endoplasmic reticulum (ER) stress-C/EBP homologues protein (CHOP) pathway to be activated during neurotrophic factor deprivation-induced apoptosis in PC12 neuronal cells and in primary cultured neurons, and this apoptosis was suppressed in the neurons from chop(-/-) mice. In addition, we found that CHOP is expressed in the subventricular zone (SVZ) and striatum of the young adult mouse brain. The number of apoptotic cells in the SVZ decreased in chop(-/-) mice. These results indicate that the ER stress-CHOP pathway plays a role in neuronal apoptosis during the development of the brain. |
