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Allele : Tnfsf9<tm1Thw> tumor necrosis factor (ligand) superfamily, member 9; targeted mutation 1, Tania H Watts

Primary Identifier	MGI:2179297	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Tnfsf9
Transmission	Germline	Strain of Origin	129
Is Recombinase	false	Is Wild Type	false

molecularNote

The gene was disrupted by insertion of a PGK-neo cassette at nucleotide 52 via homologous recombination. Activated lymph node cells from homozygous mutant animals did not contain protein product as assayed by flow cytometry.

mutations:
Insertion

cellLines:
Not Specified

synonyms:
CD137L<->,
CD137L<->,
41BBL KO,
4-1BBL-,
41BBL KO,
4-1BBL-

earliestPublication:
DeBenedette MA, et al. (1999) Analysis of 4-1BB ligand (4-1BBL)-deficient mice and of mice lacking both 4-1BBL and CD28 reveals a role for 4-1BBL in skin allograft rejection and in the cytotoxic T cell response to influenza virus. J Immunol 163(9):4833-41

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

26 Publication categories

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