| First Author | Cole F | Year | 2010 |
| Journal | Genes Dev | Volume | 24 |
| Issue | 12 | Pages | 1201-7 |
| PubMed ID | 20551169 | Mgi Jnum | J:161204 |
| Mgi Id | MGI:4457794 | Doi | 10.1101/gad.1944710 |
| Citation | Cole F, et al. (2010) Evolutionary conservation of meiotic DSB proteins: more than just Spo11. Genes Dev 24(12):1201-7 |
| abstractText | Meiotic recombination is initiated by programmed DNA double-strand breaks (DSBs) generated by the Spo11 protein. In budding yeast, five other meiotic-specific proteins are also required for DSB formation, but, with rare exception, orthologs had not been identified in other species. In this issue of Genes & Development, Kumar and colleagues (pp. 1266-1280) used a phylogenomic approach to identify two of these proteins across multiple clades, and confirmed that one of these, MEI4, is a functional ortholog in mouse. |
