| First Author | Kojima T | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 17 | Pages | 2515-20 |
| PubMed ID | 18570894 | Mgi Jnum | J:137626 |
| Mgi Id | MGI:3801367 | Doi | 10.1016/j.febslet.2008.06.014 |
| Citation | Kojima T, et al. (2008) Neostatin-7 regulates bFGF-induced corneal lymphangiogenesis. FEBS Lett 582(17):2515-20 |
| abstractText | Neostatin-7, with an anti-angiogenic potential, is generated from the proteolytic action of matrix metalloproteinase-7 on collagen XVIII. We previously reported that neostatin-7 inhibited angiogenesis in vitro and in vivo. Here we demonstrate that neostatin-7/collagen XVIII may possess anti-lymphangiogenic activities by: (1) corneal micropellet implantation of neostatin-7 reduced bFGF-induced corneal lymphangiogenesis; (2) neostatin-7 bound to VEGF receptor-3 in vitro; and (3) enhanced corneal lymphangiogenesis and VEGF-C expression in collagen XVIII knockout mice in a corneal wounding model. Understanding the mechanism of neostatin-7/collagen XVIII on corneal lymphangiogenesis may provide therapeutic interventions to treat lymphangiogenesis-related disorders, such as lymphedema, transplantation rejection and cancers. |
