| First Author | Appleby MW | Year | 1995 |
| Journal | J Exp Med | Volume | 182 |
| Issue | 3 | Pages | 811-20 |
| PubMed ID | 7650487 | Mgi Jnum | J:28280 |
| Mgi Id | MGI:75901 | Doi | 10.1084/jem.182.3.811 |
| Citation | Appleby MW, et al. (1995) Involvement of p59fynT in interleukin-5 receptor signaling [published erratum appears in J Exp Med 1995 Oct 1;182(4):1179]. J Exp Med 182(3):811-20 |
| abstractText | Previous studies implicate the nonreceptor protein tyrosine kinase (PTK) p59fyn in the propagation of signals from the B cell antigen receptor. To elucidate the functions of this kinase, we examined B cell responsiveness in mice engineered to lack the hematopoietic isoform of p59fyn. Remarkably, antigen receptor signaling was only modestly defective in fynTnull B cells. In contrast, signaling from the interleukin (IL)-5 receptor which ordinarily provides a comitogenic stimulus with antiimmunoglobulin, was completely blocked. Our results document the importance of p59fynT in IL-5 responses in B cells, and they support a general model for cytokine receptor signal transduction involving the simultaneous recruitment of at least three families of PTK. |
