| First Author | Wang F | Year | 1998 |
| Journal | Cell | Volume | 93 |
| Issue | 1 | Pages | 47-60 |
| PubMed ID | 9546391 | Mgi Jnum | J:107717 |
| Mgi Id | MGI:3621704 | Doi | 10.1016/s0092-8674(00)81145-9 |
| Citation | Wang F, et al. (1998) Odorant receptors govern the formation of a precise topographic map. Cell 93(1):47-60 |
| abstractText | Olfactory neurons expressing a given odorant receptor project with precision to 2 of the 1800 glomeruli within the olfactory bulb to create a topographic map of odor quality. We demonstrate that deletions or nonsense mutations in the P2 odorant receptor gene cause the axons of these cells to wander rather than converge on a specific glomerulus. Receptor substitution experiments that replace the P2 gene with the coding region of the P3 gene result in the projection of P3-->P2 axons to a glomerulus touching the wild-type P3 glomerulus. These data, along with additional receptor substitutions, indicate that the odorant receptor plays an instructive role in the establishment of the topographic map. |
