| First Author | Santoro SW | Year | 2012 |
| Journal | Elife | Volume | 1 |
| Pages | e00070 | PubMed ID | 23240083 |
| Mgi Jnum | J:197878 | Mgi Id | MGI:5494817 |
| Doi | 10.7554/eLife.00070 | Citation | Santoro SW, et al. (2012) The activity-dependent histone variant H2BE modulates the life span of olfactory neurons. Elife 1:e00070 |
| abstractText | We have identified a replication-independent histone variant, Hist2h2be (referred to herein as H2be), which is expressed exclusively by olfactory chemosensory neurons. Levels of H2BE are heterogeneous among olfactory neurons, but stereotyped according to the identity of the co-expressed olfactory receptor (OR). Gain- and loss-of-function experiments demonstrate that changes in H2be expression affect olfactory function and OR representation in the adult olfactory epithelium. We show that H2BE expression is reduced by sensory activity and that it promotes neuronal cell death, such that inactive olfactory neurons display higher levels of the variant and shorter life spans. Post-translational modifications (PTMs) of H2BE differ from those of the canonical H2B, consistent with a role for H2BE in altering transcription. We propose a physiological function for H2be in modulating olfactory neuron population dynamics to adapt the OR repertoire to the environment.DOI:http://dx.doi.org/10.7554/eLife.00070.001. |
