| First Author | Mintern JD | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 7 | Pages | 3283-7 |
| PubMed ID | 11907083 | Mgi Jnum | J:75582 |
| Mgi Id | MGI:2177090 | Doi | 10.4049/jimmunol.168.7.3283 |
| Citation | Mintern JD, et al. (2002) The cross-priming APC requires a Rel-dependent signal to induce CTL. J Immunol 168(7):3283-7 |
| abstractText | Induction of OVA-specific CTL by cross-priming requires help from CD4 T cells, which use CD154 to signal CD40 on the APC. To further dissect the molecular pathways involved in cross-priming, we examined the role of Rel, an NF-kappaB family member. c-rel(-/-) mice failed to generate OVA-specific CTL by cross-priming, but could induce CTL to HSV-1. Using chimeric mice, Rel expression was shown to be required by the APC, but not by the T cells. Notably, the deficiency in Rel could be overcome by triggering CD40, implying that the APC required Rel before receipt of the CD40 signal. These data suggest that the cross-priming APC must receive two signals before it can stimulate CTL. The first signal is Rel dependent and is required before activation of CD4 helper T cells, which then deliver the second signal using CD154 to trigger CD40. |
