| First Author | Bouska A | Year | 2009 |
| Journal | Cancer Res | Volume | 69 |
| Issue | 5 | Pages | 1697-701 |
| PubMed ID | 19244108 | Mgi Jnum | J:145952 |
| Mgi Id | MGI:3836360 | Doi | 10.1158/0008-5472.CAN-08-3732 |
| Citation | Bouska A, et al. (2009) Mdm2 affects genome stability independent of p53. Cancer Res 69(5):1697-701 |
| abstractText | Mdm2 is a critical negative regulator of the p53 tumor suppressor and is frequently overexpressed in human cancers. However, reports, including our own studies, suggest that Mdm2 has both p53-dependent and p53-independent functions that contribute to genomic instability and transformation when deregulated. We recently elucidated a p53-independent role for Mdm2 in the regulation of the DNA double-strand break repair response, genomic stability, and transformation through interaction with Nbs1, a member of the Mre11/Rad50/Nbs1 DNA double-strand break repair complex. In light of these findings, targeting Mdm2 in human malignancies may have effects other than activating p53. |
