| First Author | Sakata Y | Year | 2002 |
| Journal | FEBS Lett | Volume | 516 |
| Issue | 1-3 | Pages | 229-33 |
| PubMed ID | 11959138 | Mgi Jnum | J:76164 |
| Mgi Id | MGI:2178730 | Doi | 10.1016/s0014-5793(02)02529-2 |
| Citation | Sakata Y, et al. (2002) Ca(v)2.3 (alpha(1E)) Ca(2+) channel participates in the control of sperm function. FEBS Lett 516(1-3):229-33 |
| abstractText | To know the function of the Ca(2+) channel containing alpha(1)2.3 (alpha(1E)) subunit (Ca(v)2.3 channel) in spermatozoa, we analyzed Ca(2+) transients and sperm motility using a mouse strain lacking Ca(v)2.3 channel. The averaged rising rates of Ca(2+) transients induced by alpha-D-mannose-bovine serum albumin in the head region of Ca(v)2.3-/- sperm were significantly lower than those of Ca(v)2.3+/+ sperm. A computer-assisted sperm motility assay revealed that straight-line velocity and linearity were greater in Ca(v)2.3-/- sperm than those in Ca(v)2.3+/+ sperm. These results suggest that the Ca(v)2.3 channel plays some roles in Ca(2+) transients and the control of flagellar movement. |
