| First Author | Matsuda Y | Year | 2001 |
| Journal | Biochem Biophys Res Commun | Volume | 289 |
| Issue | 4 | Pages | 791-5 |
| PubMed ID | 11735114 | Mgi Jnum | J:73855 |
| Mgi Id | MGI:2156958 | Doi | 10.1006/bbrc.2001.6051 |
| Citation | Matsuda Y, et al. (2001) Mice lacking Ca(v)2.3 (alpha1E) calcium channel exhibit hyperglycemia. Biochem Biophys Res Commun 289(4):791-5 |
| abstractText | To investigate the functional role of Ca(v)2.3 channel in glucose homeostasis, we performed in vivo glucose tolerance and insulin tolerance tests together with stress-induced glucose release tests using mice deficient in Ca(v)2.3 channel (Ca(v)2.3-/-). The Ca(v)2.3-/- mice were significantly heavier than wild-type mice. In glucose tolerance and insulin tolerance tests, Ca(v)2.3-/- mice showed a significantly higher blood glucose level compared to wild-type mice. However, stress-induced blood glucose changes in Ca(v)2.3-/- mice were similar to those in wild-type mice. These results suggest that Ca(v)2.3 channel plays a role in glucose homeostasis by reducing insulin sensitivity and that Ca(v)2.3-/- mice exhibit symptoms resembling non-insulin-dependent diabetes mellitus. |
