Primary Identifier | MGI:2180141 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Cacna1d |
Transmission | Germline | Strain of Origin | 129S7/SvEvBrd-Hprt1<b-m2> |
Is Recombinase | false | Is Wild Type | false |
description | Phenotypic Similarity to Human Syndrome: Sick Sinus Syndrome J: 230439. |
molecularNote | Exon 2 was disrupted by insertion of a PGK-neo cassette via homologous recombination resulting in the introduction of multiple stop codons and translation termination before the first transmembrane domain. Absence of gene expression was verified by Western blot analysis of brain membrane protein from homozygous mutant animals. |