| Primary Identifier | MGI:2180151 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Alas2 |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | Adult chimeric mice contain typical ring sideroblasts in the bone marrow and circulating blood as seen in humans with X-linked sideroblastic anema (OMIM:30075) (J: 58508). |
| molecularNote | A neomycin selection cassette was used to replace a region including the the 5' portion of exon 8 and the 3' portion of exon 9, which encodes a lysine residue essential for binding pyridoxal 5'-phosphate (PLP). RT-PCR analysis showed an absence of message in hemizygous mutant embryos. |
