| First Author | Mehta AK | Year | 2006 |
| Journal | Mol Genet Metab | Volume | 88 |
| Issue | 1 | Pages | 86-9 |
| PubMed ID | 16406647 | Mgi Jnum | J:108196 |
| Mgi Id | MGI:3623197 | Doi | 10.1016/j.ymgme.2005.11.012 |
| Citation | Mehta AK, et al. (2006) Succinate semialdehyde dehydrogenase deficiency does not down-regulate gamma-hydroxybutyric acid binding sites in the mouse brain. Mol Genet Metab 88(1):86-9 |
| abstractText | We investigated whether succinate semialdehyde dehydrogenase deficiency alters gamma-hydroxybutyric acid (GHB) receptor characteristics due to elevation of GHB levels in the mouse brain. The membrane homogenate binding and quantitative autoradiography using [3H]NCS-382 revealed no significant changes in the affinity (Kd), receptor density (Bmax), or displacement potency (IC50) in various brain regions of Aldh5a1-/- vs. Aldh5a1+/+ mice. |
