| First Author | Bassett EA | Year | 2012 |
| Journal | Dev Dyn | Volume | 241 |
| Issue | 4 | Pages | 814-29 |
| PubMed ID | 22411557 | Mgi Jnum | J:181601 |
| Mgi Id | MGI:5312137 | Doi | 10.1002/dvdy.23762 |
| Citation | Bassett EA, et al. (2012) Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina. Dev Dyn 241(4):814-29 |
| abstractText | Background: We have previously shown that the transcription factor AP-2alpha (Tcfap2a) is expressed in postmitotic developing amacrine cells in the mouse retina. Although retina-specific deletion of Tcfap2a did not affect retinogenesis, two other family members, AP-2beta and AP-2gamma, showed expression patterns similar to AP-2alpha. Results: Here we show that, in addition to their highly overlapping expression patterns in amacrine cells, AP-2alpha and AP-2beta are also co-expressed in developing horizontal cells. AP-2gamma expression is restricted to amacrine cells, in a subset that is partially distinct from the AP-2alpha/beta-immunopositive population. To address possible redundant roles for AP-2alpha and AP-2beta during retinogenesis, Tcfap2a/b-deficient retinas were examined. These double mutants showed a striking loss of horizontal cells and an altered staining pattern in amacrine cells that were not detected upon deletion of either family member alone. Conclusions: These studies have uncovered critical roles for AP-2 activity in retinogenesis, delineating the overlapping expression patterns of Tcfap2a, Tcfap2b, and Tcfap2c in the neural retina, and revealing a redundant requirement for Tcfap2a and Tcfap2b in horizontal and amacrine cell development. Developmental Dynamics 241:814-829, 2012. (c) 2012 Wiley Periodicals, Inc. |
