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Allele : Lefty2<tm1Hmd> left-right determination factor 2; targeted mutation 1, Hiroshi Hamada

Primary Identifier	MGI:2179551	Allele Type	Targeted
Attribute String	Null/knockout	Gene	Lefty2
Transmission	Germline	Strain of Origin	129P2/OlaHsd
Is Recombinase	false	Is Wild Type	false

molecularNote

All 4 exons of this gene were replaced with a neomycin resistance cassette via homologous recombination. Homozygous mutant embryos at E8.5 and E11.5 were identified by Southern blot analysis.

mutations:
Intragenic deletion,
Insertion

cellLines:
Not Specified

synonyms:
lefty2-,
lefty2-

earliestPublication:
Meno C, et al. (1999) Mouse Lefty2 and zebrafish antivin are feedback inhibitors of nodal signaling during vertebrate gastrulation. Mol Cell 4(3):287-98

1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

Other

1 Carried By

0 Driven By

6 Publication categories

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