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Allele : Nfkb2<tm1Brv> nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; targeted mutation 1, Rodrigo Bravo

Primary Identifier  MGI:2179689 Allele Type  Targeted
Attribute String  Null/knockout Gene  Nfkb2
Transmission  Germline Strain of Origin  129S1/Sv-Oca2<+> Tyr<+> Kitl<+>
Is Recombinase  false Is Wild Type  false
molecularNote  The carboxy terminal domain of the protein was disrupted by insertion of a termination codon at position 451 and the replacement of the sequences encoding residues 451 to 690 with a neomycin resistance cassette. Immunoprecipitation analysis on lysates of stimulated thymocytes demonstrated that the larger precursor protein was not made, but a processed and truncated p52 protein was present.
  • mutations:
  • Insertion
  • synonyms:
  • p100-,
  • p100-
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

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17 Publication categories

Trail: Allele