| First Author | Liu Y | Year | 1997 |
| Journal | J Exp Med | Volume | 185 |
| Issue | 2 | Pages | 251-62 |
| PubMed ID | 9016874 | Mgi Jnum | J:76970 |
| Mgi Id | MGI:2180688 | Doi | 10.1084/jem.185.2.251 |
| Citation | Liu Y, et al. (1997) Distinct costimulatory molecules are required for the induction of effector and memory cytotoxic T lymphocytes. J Exp Med 185(2):251-62 |
| abstractText | A successful T cell immune response has two major products: effector T cells which directly or indirectly remove the antigens, and memory T cells, which allow a faster and more efficient recall response when challenged by related antigens. An important issue is whether costimulatory molecules on the antigen-presenting cells are involved in determining whether T cells will differentiate into effector or memory cells after antigenic stimulation. To address this issue, we have produced mice with targeted mutations of either the heat-stable antigen (HSA), or both HSA and CD28. We show that CD28/B7 and HSA provide two alternative costimulatory pathways for induction of immunological memory to influenza virus. Furthermore, our results revealed that B7 is essential for the generation of effector T cells from either naive or memory T cells, while HSA is not necessary for the generation of effector T cells. Our results demonstrate that the induction of memory T cells and effector T cells can utilize distinct costimulatory molecules. These results have important implications on lineage relationship between effector and memory T cells. |
