| First Author | Clements JL | Year | 1998 |
| Journal | Science | Volume | 281 |
| Issue | 5375 | Pages | 416-9 |
| PubMed ID | 9665885 | Mgi Jnum | J:76697 |
| Mgi Id | MGI:2179983 | Doi | 10.1126/science.281.5375.416 |
| Citation | Clements JL, et al. (1998) Requirement for the leukocyte-specific adapter protein SLP-76 for normal T cell development. Science 281(5375):416-9 |
| abstractText | The leukocyte-specific adapter molecule SLP-76 (Src homology 2 domain-containing leukocyte protein of 76 kilodaltons) is rapidly phosphorylated on tyrosine residues after receptor ligation in several hematopoietically derived cell types. Mice made deficient for SLP-76 expression contained no peripheral T cells as a result of an early block in thymopoiesis. Macrophage and natural killer cell compartments were intact in SLP-76-deficient mice, despite SLP-76 expression in these lineages in wild-type mice. Thus, the SLP-76 adapter protein is required for normal thymocyte development and plays a crucial role in translating signals mediated by pre-T cell receptors into distal biochemical events. |
