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Publication : Evidence for function of UDP galactose pyrophosphorylase in mice with absent galactose-1-phosphate uridyltransferase.

First Author  Wehrli S Year  2007
Journal  Mol Genet Metab Volume  91
Issue  2 Pages  191-4
PubMed ID  17433749 Mgi Jnum  J:122348
Mgi Id  MGI:3714101 Doi  10.1016/j.ymgme.2007.02.013
Citation  Wehrli S, et al. (2007) Evidence for function of UDP galactose pyrophosphorylase in mice with absent galactose-1-phosphate uridyltransferase. Mol Genet Metab 91(2):191-4
abstractText  Mice with deletion of the galactose-1-phosphate uridyltransferase (GALT) gene were examined for their ability to form (13)C labeled hepatic UDP glucose from administered 1-(13)C galactose. NMR analysis of urinary acetaminophen glucuronide, which is derived from hepatic UDP glucose showed (13)C enrichment after concomitant administration of (13)C galactose and acetaminophen. The finding is consistent with the function of UDP galactose pyrophosphorylase as an alternate pathway of galactose metabolism.
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