| First Author | Tamada K | Year | 2002 |
| Journal | J Immunol | Volume | 168 |
| Issue | 10 | Pages | 4832-5 |
| PubMed ID | 11994431 | Mgi Jnum | J:76414 |
| Mgi Id | MGI:2179373 | Doi | 10.4049/jimmunol.168.10.4832 |
| Citation | Tamada K, et al. (2002) Cutting Edge: Selective Impairment of CD8(+) T Cell Function in Mice Lacking the TNF Superfamily Member LIGHT. J Immunol 168(10):4832-5 |
| abstractText | Interactions of LIGHT and its receptors, herpesvirus entry mediator on T cells and lymphotoxin beta receptor on stromal cells, are implicated in the regulation of lymphoid organogenesis, costimulation of T cells, and activation of dendritic cells. In this work we report that LIGHT-deficient mice had normal lymphoid organs with T cells and APCs that normally responded to Ag stimulation and normally stimulated T cells. Although the number of Vbeta8(+) T cells in naive LIGHT(+/+) and LIGHT(-/-) mice was identical, Vbeta8(+)CD8(+) T cell proliferation in response to staphylococcal enterotoxin B was significantly lower in LIGHT(-/-) mice. Consistently, induction and cytokine secretion of CD8(+) CTL to MHC class I-restricted peptide was also reduced in LIGHT(-/-) mice. However, the proliferative response of Vbeta8(+)CD4(+) T cells to staphylococcal enterotoxin B was comparable in LIGHT(-/-) and LIGHT(+/+) mice. Our results suggest that LIGHT is required for activation of normal CD8(+) T cells but not CD4(+) T cells. |
