| Primary Identifier | MGI:2180360 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Itpr1 |
| Transmission | Germline | Strain of Origin | 129S4/SvJae |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A neomycin cassette was inserted into the first coding exon of the gene which contains 5' untranslated sequence and the sequence for the first 31 amino acids. A lack of protein from the cerebellum of homozygous mutant animals was demonstrated by Western analysis. Additional binding studies and Ca2+ release assays were incorporated to demonstrate the loss of function for this allele. |
