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Publication : Emergence of noise-induced oscillations in the central circadian pacemaker.

First Author  Ko CH Year  2010
Journal  PLoS Biol Volume  8
Issue  10 Pages  e1000513
PubMed ID  20967239 Mgi Jnum  J:167074
Mgi Id  MGI:4867127 Doi  10.1371/journal.pbio.1000513
Citation  Ko CH, et al. (2010) Emergence of noise-induced oscillations in the central circadian pacemaker. PLoS Biol 8(10):e1000513
abstractText  Bmal1 is an essential transcriptional activator within the mammalian circadian clock. We report here that the suprachiasmatic nucleus (SCN) of Bmal1-null mutant mice, unexpectedly, generates stochastic oscillations with periods that overlap the circadian range. Dissociated SCN neurons expressed fluctuating levels of PER2 detected by bioluminescence imaging but could not generate circadian oscillations intrinsically. Inhibition of intercellular communication or cyclic-AMP signaling in SCN slices, which provide a positive feed-forward signal to drive the intracellular negative feedback loop, abolished the stochastic oscillations. Propagation of this feed-forward signal between SCN neurons then promotes quasi-circadian oscillations that arise as an emergent property of the SCN network. Experimental analysis and mathematical modeling argue that both intercellular coupling and molecular noise are required for the stochastic rhythms, providing a novel biological example of noise-induced oscillations. The emergence of stochastic circadian oscillations from the SCN network in the absence of cell-autonomous circadian oscillatory function highlights a previously unrecognized level of circadian organization.
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