| First Author | Heimerl S | Year | 2008 |
| Journal | Biochem Biophys Res Commun | Volume | 367 |
| Issue | 4 | Pages | 826-33 |
| PubMed ID | 18191037 | Mgi Jnum | J:131294 |
| Mgi Id | MGI:3773466 | Doi | 10.1016/j.bbrc.2008.01.010 |
| Citation | Heimerl S, et al. (2008) Caveolin-1 deficiency alters plasma lipid and lipoprotein profiles in mice. Biochem Biophys Res Commun 367(4):826-33 |
| abstractText | Caveolae are specialized membrane microdomains formed as the result of local accumulation of cholesterol, glycosphingolipids, and the structural protein caveolin-1 (Cav-1). To further elucidate the role of Cav-1 in lipid homeostasis in-vivo, we analyzed fasting and post-prandial plasma from Cav-1 deficient mice on low or on high fat diet. In total plasma analysis, an increase in ceramide and hexosylceramide was observed. In cholesteryl ester (CE), we found an increased saturated+monounsaturated/polyunsaturated fatty acid ratio in fasting plasma of low fat fed Cav-1(-/-) mice with increased proportions of CE16:1, CE18:1, CE20:3, and decreased proportions of CE18:2 and CE22:6. Under high fat diet HDL-CE, free cholesterol and pre-beta-HDL were increased accompanied by a shift from slow to fast migrating alpha-HDL and expansion of apoE containing HDL. Our results demonstrate a significant role of Cav-1 in HDL-cholesterol metabolism and may reflect a variety of Cav-1 functions including modulation of ACAT activity and SR-BI function. |
