| First Author | Meng Y | Year | 2004 |
| Journal | Neuropharmacology | Volume | 47 |
| Issue | 5 | Pages | 746-54 |
| PubMed ID | 15458846 | Mgi Jnum | J:97186 |
| Mgi Id | MGI:3574713 | Doi | 10.1016/j.neuropharm.2004.06.030 |
| Citation | Meng Y, et al. (2004) Regulation of ADF/cofilin phosphorylation and synaptic function by LIM-kinase. Neuropharmacology 47(5):746-54 |
| abstractText | To investigate the role of the LIM-kinase (LIMK) family in the regulation of ADF/cofilin phosphorylation and synaptic function in the mammalian central nervous system (CNS), we conducted biochemical and electrophysiological analysis using mice that were genetically altered in the expression of LIMK-1 and LIMK-2. We showed here that while LIMK-2 knockout mice exhibited minimal abnormalities, the LIMK-1/2 double knockout mice were more severely impaired in both ADF/cofilin phosphorylation and excitatory synaptic function in the CA1 region of the hippocampus. These results indicate a critical role for the LIMK family in the regulation of ADF/cofilin and synaptic function in the brain. |
