| First Author | Durak O | Year | 2015 |
| Journal | Mol Psychiatry | Volume | 20 |
| Issue | 3 | Pages | 388-97 |
| PubMed ID | 24821222 | Mgi Jnum | J:315769 |
| Mgi Id | MGI:6831472 | Doi | 10.1038/mp.2014.42 |
| Citation | Durak O, et al. (2015) Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of beta-catenin. Mol Psychiatry 20(3):388-97 |
| abstractText | Ankyrin-G is a scaffolding protein required for the formation of the axon initial segment in neurons. Recent genome-wide association studies and whole-exome sequencing have identified ANK3, the gene coding for ankyrin-G, to be a risk gene for multiple neuropsychiatric disorders, such as bipolar disorder, schizophrenia and autism spectrum disorder. Here, we describe a novel role for ankyrin-G in neural progenitor proliferation in the developing cortex. We found that ankyrin-G regulates canonical Wnt signaling by altering the subcellular localization and availability of beta-catenin in proliferating cells. Ankyrin-G loss-of-function increases beta-catenin levels in the nucleus, thereby promoting neural progenitor proliferation. Importantly, abnormalities in proliferation can be rescued by reducing Wnt pathway signaling. Taken together, these results suggest that ankyrin-G is required for proper brain development. |
