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Allele : Snta1<tm1Scf> syntrophin, acidic 1; targeted mutation 1, Stanley C Froehner

Primary Identifier  MGI:2179769 Allele Type  Targeted
Attribute String  Null/knockout Gene  Snta1
Transmission  Germline Strain of Origin  129P2/OlaHsd
Is Recombinase  false Is Wild Type  false
molecularNote  A neomycin resistance cassette replaced a genomic fragment containing exon 1, which encodes the first 97 amino acids including part of the PH domain and part of the PDZ domain. Northern blot analysis on RNA derived from skeletal muscle of homozygous mice demonstrated that aberrant transcripts were expressed from this allele, but immunoprecipitation experiments confirmed that no detectable encoded protein was present in skeletal muscle of homozygous mice.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • alpha-Syn -/-,
  • alphaSynKO,
  • alpha-Syn -/-,
  • alphaSynKO
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

41 Publication categories