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Publication : Lack of the PAC1 receptor alters the circadian expression of VIP mRNA in the suprachiasmatic nucleus of mice.

First Author  Georg B Year  2007
Journal  Brain Res Volume  1135
Issue  1 Pages  52-7
PubMed ID  17196185 Mgi Jnum  J:118186
Mgi Id  MGI:3698893 Doi  10.1016/j.brainres.2006.12.001
Citation  Georg B, et al. (2007) Lack of the PAC(1) receptor alters the circadian expression of VIP mRNA in the suprachiasmatic nucleus of mice. Brain Res 1135(1):52-7
abstractText  PACAP in the retinohypothalamic tract mediates photic information to the suprachiasmatic nucleus via the PAC(1) receptor. The diurnal and circadian VIP mRNA expressions in the suprachiasmatic nucleus of PAC(1)-/- and wild type mice were quantified. During light/dark cycles identical VIP mRNA rhythms were found while the oscillation pattern differed between the two types of animals during constant darkness. The results show that the circadian VIP mRNA expression is influenced by the absence of PAC(1) signalling.
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